Can tissue regeneration occur without stem cells?

Yes, tissue regeneration can also rely on the multiplication of specialized cells to restore the damaged tissue. This process is dependent on the plasticity of specialized cells around the wounded tissue. For example, the liver can recover after partial damage (for example after a hepatectomy) through the proliferation of the remaining liver cells. Among vertebrates, salamanders can regenerate amputated limbs by mobilizing the functional cells in the remaining stump. Understanding how mature tissues are activated in response to injury will provide new insights into developing regenerative therapies.